Genotoxic Compounds

This compact conference on genotoxic compounds offers a unique platform for interaction among regulatory, industrial, and scientific professionals. It focuses on agrochemicals, chemicals, biocides, cosmetics, pharmaceuticals, food, feed, and food contact materials. Attendees can expect to gain valuable insights into the latest advancements in regulation, quantitative risk assessment, test methods and guidelines. They will understand the implications for their specific industries, and learn about modelling and prediction. This event promises to be a crucial opportunity to stay informed and updated in this rapidly evolving field.

Highlights:

Regulatory developments and policy direction

• EU Roadmap towards phasing out animal testing
• PARC and regulatory developments
• NAMs in genotoxicity and carcinogenicity assessment
• ICH Q3E implications for genotoxic impurities, extractables and leachables

From hazard to risk: Quantitative approaches

• Aneugens and quantitative assessment strategies
• HESI GTTC activities and IWGT learnings

NAMs and mechanistic tools

• Error-corrected next-generation sequencing (ecNGS)
• Mechanistic assays and OECD developments

Integrated testing strategies

• Current and future role of in vivo testing
• Botanical and cosmetic case studies
• Weight-of-evidence approaches

In silico approaches and data integration

• OECD and EFSA developments for metabolite assessment
• (Q)SAR, read-across and databases
• Integration into non-animal strategies

Who should attend this conference?

Professionals working in the fields of:

• Toxicology
• Hazard, exposure and risk assessment for human health
• Registration & regulatory affairs
• Research and development
• Legal and general counselling

Sectors that should take part:

• Agrochemical industry
• Biocide industry
• Chemical industry
• Pharmaceutical industry
• Cosmetic industry
• Food and feed industry
• Packaging industry
• Research institutes
• Regulatory authorities
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